Ketogenic Diet in Infants with Refractory Epilepsy

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Ketogenic diet guidelines for infants with refractory epilepsy.

BACKGROUND The ketogenic diet (KD) is an established, effective non-pharmacologic treatment for drug resistant childhood epilepsy. For a long time, the KD was not recommended for use in infancy (under the age of 2 years) because this is such a crucial period in development and the perceived high risk of nutritional inadequacies. Indeed, infants are a vulnerable population with specific nutritio...

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Assessment and follow up of the children with refractory epilepsy on ketogenic diet

Introduction: The ketogenic diet is a method of treatment that is recommended for patients with epilepsy who have not responded to medications. The present study was designed to evaluate the efficacy of the ketogenic diet along with follow-up on drug resistant epilepsy in children referred to medical centers affiliated to Shiraz University of Medical Sciences. Methods: This study was a multicen...

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Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy

AIM To investigate whether patients with refractory epilepsy and healthy infants differ in gut microbiota (GM), and how ketogenic diet (KD) alters GM. METHODS A total of 14 epileptic and 30 healthy infants were recruited and seizure frequencies were recorded. Stool samples were collected for 16S rDNA sequencing using the Illumina Miseq platform. The composition of GM in each sample was analyz...

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Neurobiochemical mechanisms of a ketogenic diet in refractory epilepsy

A ketogenic diet is an important therapy used in the control of drug-refractory seizures. Many studies have shown that children and adolescents following ketogenic diets exhibit an over 50% reduction in seizure frequency, which is considered to be clinically relevant. These benefits are based on a diet containing high fat (approximately 90% fat) for 24 months. This dietary model was proposed in...

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[Ketogenic diet for the treatment of refractory epilepsy].

OBJECTIVES To systematically review and synthesize the available evidence on the efficacy of the ketogenic diet in reducing seizure frequency for children with refractory epilepsy. DATA SOURCES Medline searches were performed using the keywords epilepsy/therapy, dietary therapy, and epilepsy, and the text word ketogenic diet. The Cochrane Library of clinical trials was searched using the term...

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ژورنال

عنوان ژورنال: AAP Grand Rounds

سال: 2001

ISSN: 1099-6605

DOI: 10.1542/gr.6-3-26